Beilstein J. Org. Chem.2018,14, 1885–1889, doi:10.3762/bjoc.14.162
retained in solution.
Keywords: CTV; hemicryptophanes; organic cages; triplehelicalstructure; Introduction
Among the remarkable architectures found in biological systems, those presenting a triple helical arrangement are of particular interest. Beside its classical double strand structure formed by
Watson–Crick base pairing, DNA can also organize in a triple helical fashion [1]. These three-stranded structures of DNA naturally occur and play important roles in regulating gene function and DNA metabolism. Collagen, the most abundant protein in animals, also adopts a triplehelicalstructure: three
a better understanding of the properties of this biological system and giving rise to numerous applications ranging from artificial collagenous biomaterials to peptides for therapeutic uses [3][4][5].
Recently, molecular cages presenting a triplehelicalstructure have aroused a considerable
Beilstein J. Org. Chem.2010,6, No. 20, doi:10.3762/bjoc.6.20
stoichiometry, similar to homo-polymeric thymidyl and adenyl DNA strands, which can form a triplehelicalstructure. On the other hand, octameric cytidyl DNG 59 and mixed-based oligomers 61–63 form 1:1 complexes with complementary DNA oligomers. The trimeric 7-deazaguanidyl 60, in which guanine is replaced by 7
PDF
Graphical Abstract
Figure 1:
Schematic representation of sugar aminoacids (SAAs) and (pseudo)amide oligosaccharide mimetics.